Monday, October 23, 2017

Jack Chan's Weekly Precious Metals Update

Source: Jack Chan for Streetwise Reports   10/23/2017

Technical analyst Jack Chan charts the latest moves in the gold and silver markets.jack chan1.png

Our proprietary cycle indicator turned down this week.

jack chan2.png

Gold sector is on a long-term buy signal.

Long-term signals can last for months and years and are more suitable for investors holding for long term.

jack chan3.png

Gold sector is on a short-term sell signal.

Short-term signals can last for days and weeks, and are more suitable for traders.

jack chan4.png

Speculation favors overall higher gold prices.

jack chan5.png

A potential inverted head & shoulder bottoming pattern is in progress, and a breakout on the dollar will pressure the metals further.

jack chan 6.png

Silver is on a long-term buy signal.

jack chan7.png

SLV is on a short-term buy signal, and short-term signals can last for days to weeks, more suitable for traders.

jack chan8.png

Speculation favors overall higher silver prices.

Summary

The precious metals sector is on major buy signal.

Cycle is down, as consolidation continues.

COT data is supportive for overall higher metal prices.

We are holding gold related ETFs for long-term gain.

Jack Chan is the editor of simply profits at www.simplyprofits.org, established in 2006. Chan bought his first mining stock, Hoko Exploration, in 1979, and has been active in the markets for the past 37 years. Technical analysis has helped him filter out the noise and focus on the when, and leave the why to the fundamental analysts. His proprietary trading models have enabled him to identify the NASDAQ top in 2000, the new gold bull market in 2001, the stock market top in 2007, and the U.S. dollar bottom in 2011.

Want to read more Gold Report articles like this? Sign up for our free e-newsletter, and you'll learn when new articles have been published. To see a list of recent articles and interviews with industry analysts and commentators, visit our Streetwise Interviews page.

Disclosure:
1) Statements and opinions expressed are the opinions of Jack Chan and not of Streetwise Reports or its officers. Jack Chan is wholly responsible for the validity of the statements. Streetwise Reports was not involved in any aspect of the article preparation or editing so the author could speak independently about the sector. The author was not paid by Streetwise Reports LLC for this article. Streetwise Reports was not paid by the author to publish or syndicate this article.
2) Jack Chan: We do not offer predictions or forecasts for the markets. What you see here is our simple trading model, which provides us the signals and set-ups to be either long, short, or in cash at any given time. Entry points and stops are provided in real time to subscribers, therefore, this update may not reflect our current positions in the markets. Trade at your own discretion. We also provide coverage to the major indexes and oil sector.
3) This article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.

Charts courtesy of Jack Chan



from Streetwise Reports - Exclusive Articles https://www.streetwisereports.com/pub/na/17781

Silver Is Underperforming Gold

Source: Clive Maund for Streetwise Reports   10/22/2017

Technical analyst Clive Maund charts silver and discusses its relationship with gold.

Like gold, silver now appears to be completing an intermediate Head-and-Shoulders top within a much larger and very bullish Head-and-Shoulders bottom pattern. Both these Head-and-Shoulders tops are related to the Head-and-Shoulders bottom completing in the dollar index, that we look at in the parallel Gold Market update.

On silver's latest 6-month chart we can see how the gap breakout out of the small Falling Wedge downtrend over a week ago did not lead to follow through, and instead the price has moved to complete the Right Shoulder of the now clearly discernable Head-and-Shoulders top that has been forming since the beginning of August. It should now descend to the "neckline" of the pattern before proceeding to break down below it and drop into the broad band of support shown as the dollar index ascends to its target in the 97 area, where silver should bottom out and turn up again as the dollar reverses to the downside having hit its target.

Although silver's recent COT charts cannot be described as bullish, they have looked better than those for gold, but this past week, unlike gold's, they took a turn for the worse. There is plenty of room for improvement here, which will be occasioned by silver breaking lower and dropping to the $16 area on a dollar rally.

Click on chart to popup a larger clearer version.

Like gold, silver is marking out a giant Head-and-Shoulders bottom pattern, but in silver’s case it is downsloping as we can see on its 8-year chart below, which reflects the fact that silver tends to underperform gold at the end of sector bear markets and during the early stages of sector bull markets. Prolonged underperformance by silver is therefore a sign of a bottom. This chart really does show how unloved silver is right now, but although the price has drifted slightly lower over the past several years, volume indicators have improved, especially this year, a positive sign. A break above the neckline of the pattern, the black line, will be a positive development, and more so a break above the band of resistance approaching the 2016 highs. Once it gets above this it will have to contend with a quite strong zone of resistance roughly between $26 and $28. Over the short to medium-term, however, as discussed above, silver is likely to first react back to the $16 area on a dollar rally.

Clive Maund has been president of www.clivemaund.com, a successful resource sector website, since its inception in 2003. He has 30 years' experience in technical analysis and has worked for banks, commodity brokers and stockbrokers in the City of London. He holds a Diploma in Technical Analysis from the UK Society of Technical Analysts.

Want to read more Gold Report articles like this? Sign up at www.streetwisereports.com/get-news for our free e-newsletter, and you'll learn when new articles have been published. To see recent articles with industry analysts and commentators, visit our Streetwise Interviews page.

Disclosure:
1) Statements and opinions expressed are the opinions of Clive Maund and not of Streetwise Reports or its officers. Clive Maund is wholly responsible for the validity of the statements. Streetwise Reports was not involved in the content preparation. Clive Maund was not paid by Streetwise Reports LLC for this article. Streetwise Reports was not paid by the author to publish or syndicate this article.
2) This article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.

Charts provided by the author.



from Streetwise Reports - Exclusive Articles https://www.streetwisereports.com/pub/na/17782

Dollar Getting Ready to Rally

Source: Clive Maund for Streetwise Reports   10/22/2017

Technical analyst Clive Maund discusses the outlook for the U.S. dollar and its implications for gold.

The dollar is getting ready for a sizable rally, and that means that gold and silver are going to be knocked back again. Longer term however, the outlook for the Precious Metals could scarcely be better, as we will see.

In last weekend's update it was pointed out that gold's gap breakout from its steep downtrend shown on its latest 6-month chart below was probably false and that it was expected to drop back as the dollar advanced, which it duly did last week. Bearing in mind that the dollar has about completed its Head-and-Shoulders bottom, it is now clear that a parallel Head-and-Shoulders top is completing in gold as shown on the chart. This chart projects a breakdown beneath the nearby support level to be followed by a drop targeting the quite strong support in the $1200–$1215 area.

Gold’s latest COT chart still looks more bearish than bullish, with a lot of room for improvement, such as would be occasioned by a drop to the $1200–$1215 area.

Click on chart to popup a larger, clearer version.

On gold's 8-year chart it continues to look like it is in the late stages of a giant Head-and-Shoulders bottom pattern. The buildup in volume over the past 20 months certainly looks positive, especially over the past several months, all the more so because it has driven volume indicators higher, notably the Accum-Distrib line, which is not far off making new highs—exceeding its level at the 2011 peak. Once gold breaks above the resistance level approaching $1400 it will be on its way, although it will then have to contend with another important band of resistance in the $1510–$1560 range. A near-term retreat by gold to the $1200–$1215 area in the face of a dollar rally will not damage this long-term technical picture.


The Market Vectors Gold Miners, GDX, which functions as a gold stocks index, is marking out a giant Head-and-Shoulders bottom that roughly parallels the one completing in gold itself. A near-term decline to $20-$21 in GDX will be viewed as presenting another important buying opportunity for the sector. The volume pattern during the build out of this base pattern is very bullish, with big volume on the rise out of the low (Head) of the pattern, tailing off steadily as the Right Shoulder has formed.


The latest 6-month chart for GDX shows an upsloping Head-and-Shoulders top completing which parallels the one completing in gold itself. This pattern targets strong support in the $20-$21 area following the expected breakdown.


Over the past several weeks the dollar has behaved exactly as predicted in recent updates, as it has dropped back to complete the Right Shoulder of its Head-and-Shoulders bottom, and last week started to advance towards the upper boundary or "neckline" of the pattern in readiness for the upside breakout and advance. This Head-and-Shoulder bottom targets the 97 area as shown, near to the falling 200-day moving average…


Our prediction made many weeks ago that the dollar would rally off the lower boundary of its big bullhorn pattern shown on the 4-year chart below to break out above its restraining Dome has proven to be correct, and a projection has been drawn on this chart showing roughly what is expected to happen. As we saw above on the 8-month chart, the base pattern now approaching completion targets the 97 area approx. This is the "swansong rally"—the dollar's last rally before it "hands in its dinner pail," and should present a wonderful last opportunity to accumulate the better gold and silver stocks, before the dollar does an about face, and breaks down from the large Broadening Top pattern into a severe decline.


The Hedgers chart has been warning for weeks that the dollar will reverse and rally, as has been pointed out repeatedly. The latest chart shows that the rally is still ahead of us—which is congruent with the dollar having completed a valid Head-and-Shoulders bottom.

Click on chart to popup a larger, clearer version.

Chart courtesy of www.sentimentrader.com

Finally, it is a matter of conjecture what will drive a dollar rally over the medium-term, but one possibility is an escalation of the Catalonia crisis, with the Madrid government attempting fascist style repression of the Catalonian's drive for independence leading to conflict. Both Madrid and the European Union have an interest in crushing the Catalonians, since both profit from centralization of power. Thus to whatever extent the Catalonians are successful, it will inspire other would be breakaway regions across Europe, further undermining the European Union and thus putting pressure on the euro, hence a dollar index rally, as the dollar index is made up approximately 57% of the euro.

Clive Maund has been president of www.clivemaund.com, a successful resource sector website, since its inception in 2003. He has 30 years' experience in technical analysis and has worked for banks, commodity brokers and stockbrokers in the City of London. He holds a Diploma in Technical Analysis from the UK Society of Technical Analysts.

Want to read more Gold Report articles like this? Sign up at www.streetwisereports.com/get-news for our free e-newsletter, and you'll learn when new articles have been published. To see recent articles with industry analysts and commentators, visit our Streetwise Interviews page.

Disclosure:
1) Clive Maund: I, or members of my immediate household or family, own shares of the following companies mentioned in this article: None. I personally am, or members of my immediate household or family are, paid by the following companies mentioned in this article: None. My company has a financial relationship with the following companies referred to in this article: None. I determined which companies would be included in this article based on my research and understanding of the sector.
2) The following companies mentioned in this article are sponsors of Streetwise Reports: None. Streetwise Reports does not accept stock in exchange for its services. Click here for important disclosures about sponsor fees. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
3) Statements and opinions expressed are the opinions of the author and not of Streetwise Reports or its officers. The author is wholly responsible for the validity of the statements. The author was not paid by Streetwise Reports for this article. Streetwise Reports was not paid by the author to publish or syndicate this article.4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article, until one week after the publication of the interview or article.

Charts provided by the author.



from Streetwise Reports - Exclusive Articles https://www.streetwisereports.com/pub/na/17780

Reverse Takeover for Explorer in the Golden Triangle

Source: Streetwise Reports   10/19/2017

A company chaired by mining veteran Larry Nagy that has rights to a project in northern British Columbia's Golden Triangle has completed a reverse takeover and begins trading on the TSX Venture Exchange on Oct. 19.

Golden Ridge Resources Ltd. (GLDN:TSX.V) has announced that the TSX Venture Exchange has accepted for filing 88 Capital Corp.'s reverse takeover and related transactions, "including the acquisition of all of the issued and outstanding shares of Golden Ridge Resources." The company begins trading on the TSX Venture Exchange Oct. 19 under the symbol GLDN.

Veteran mine finder Larry Nagy chairs Golden Ridge. He was part of the discovery team at both the Eskay Creek, Canada's highest-grade gold mine, and Snip, another high-grade mine in the Golden Triangle.

The company has an option to earn 100% interest in the Hank gold-silver-copper property in the Golden Triangle in northern British Columbia. This area is home to large deposits such as Pretium's Brucejack and Seabridge Gold's KSM project.

Golden Ridge's optioned the Hank property from Barrick Gold, which acquired the project when it took over Lac Minerals. According to the company, Golden Ridge can earn a "100% interest by performing $1.7-million of exploration work by the end of 2018; this is subject to a certain back-in provision if a deposit equals or exceeds three million ounces of gold in the mineral resource category."

Historical drilling comprising 13,709 meters in 104 holes on the Hank project intercepted two zones: the Upper Alternation Zone with high-grade, epithermal sulphide veins, and the Lower Alteration Zone with a polymetallic minerals. The historical reserve is 50,000 ounces of gold at surface. The company will conduct a 7,500-meter exploration program that will drill much deeper than what was conducted historically to test the theory that grades will increase at depth.

The company announced on Sept. 1 that it has completed a $5.24 million private placement, an increase from the originally announced $3 million. Approximately 32.6 million units were issued at $0.125 per unit, and 7.5 million flow-through shares were issued at $0.15 per share.

Want to read more Gold Report articles like this? Sign up for our free e-newsletter, and you'll learn when new articles have been published. To see a list of recent articles and interviews with industry analysts and commentators, visit our Streetwise Interviews page.

Streetwise Reports Disclosure:
1) Patrice Fusillo compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee. She owns, or members of her immediate household or family own, securities of the following companies mentioned in this article: None. She is, or members of her immediate household or family are, paid by the following companies mentioned in this article: None.

2) The following companies mentioned in the article are billboard sponsors of Streetwise Reports: Pretium Resources and Seabridge Gold. Streetwise Reports does not accept stock in exchange for its services. Click here for important disclosures about sponsor fees. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article, until one week after the publication of the interview or article. As of the date of this interview, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Golden Ridge Resources, a company mentioned in this article.

( Companies Mentioned: GLDN:TSX.V, )



from Streetwise Reports - Exclusive Articles https://www.streetwisereports.com/pub/na/17777

Thursday, October 19, 2017

Columbus Gold Is Giving Free Shares Away

Source: Bob Moriarty for Streetwise Reports   10/18/2017

Bob Moriarty of 321 Gold discusses Columbus Gold's imminent spinout of its Nevada properties.

I have followed Columbus Gold Corp. (CGT:TSX; CBGDF:OTCQX) since I first wrote about them in 2014. Their main gold project is in French Guiana and is part of a JV with a Russian company. It's a great project with 2.75 million ounces of proven and probable reserves of gold. Columbus Gold owns 45% and Nordgold owns 55%. At $1200 gold the project has an after tax IRR of 23% and an NPV of $324 million US. Owning 45% should make CGT's interest worth $145 million US or about $185 million CAD. Instead Columbus has a market cap of right at $100 million CAD.

And they own 14 projects in Nevada including one with a 721,000 gold equivalent ounce resource. Management realized they are not getting any value out of the Nevada projects so they are spinning them off into a new company named Allegiant. That's where the free shares come into the deal.

Columbus is holding a special meeting the 20th of November for shareholders to vote on the spinout. Shareholders as of the Share Distribution Record Date will receive 1/5th of a share of Allegiant for every Columbus share held. The company anticipates the record date to be four business days after the meeting or the 24th of November. So if you own 10,000 shares of Columbus on the Record Date, you will be handed 2,000 shares of Allegiant.

That's a hell of a deal for a couple of reasons. Andy Wallace is going to be the CEO of Allegiant. As a manager and now owner of Cordex, he helped the company find an incredible eight gold mine discoveries in Nevada including the five million ounce Marigold Mine, the twelve million ounce Lone Tree Mine and the Daisy Mine.

Allegiant plans on drilling ten projects of the fourteen in the first twelve months. Their two most important projects are Eastside with an existing 721,000 gold equivalent ounce resource and a historic gold resource of 270,000 ounces and the Bolo project northeast of Tonopah. Columbus recently drilled 14 RC holes at Bolo about 500 meters south of a historic hole returning 30.5 meters of 3.24 g/t gold, 12.2 meters of 3.05 g/t gold and 19.8 meters of 1.1 g/t gold. The company is not going to release the results of the drilling until after the spinout is complete. They anticipate assays being back about mid-December.

Columbus is in the process of setting up a non-brokered private placement with terms not yet disclosed. The shares will be free trading right out of the chute.

The spinout is brilliant for creating more value to both Columbus and existing shareholders. Columbus will get 13% of the new shares, existing shareholders will get 52% and new investors will receive about 35% of Allegiant. Allegiant will be well funded for a major 2017-2018 exploration program.

Columbus Gold is not an advertiser. I bought shares in the open market that I intend to hold through the record date and I am participating in the private placement. Do your own due diligence.

Columbus Gold
CGT-T $0.65 (Oct 20, 2017)
CBGDF-OTCBB 153 million shares
Columbus Gold website

Bob and Barb Moriarty brought 321gold.com to the Internet almost 16 years ago. They later added 321energy.com to cover oil, natural gas, gasoline, coal, solar, wind and nuclear energy. Both sites feature articles, editorial opinions, pricing figures and updates on current events affecting both sectors. Previously, Moriarty was a Marine F-4B and O-1 pilot with more than 832 missions in Vietnam. He holds 14 international aviation records.

Want to read more Gold Report articles like this? Sign up for our free e-newsletter, and you'll learn when new articles have been published. To see a list of recent articles and interviews with industry analysts and commentators, visit our Streetwise Interviews page.

Disclosure:
1) Bob Moriarty: I, or members of my immediate household or family, own shares of the following companies mentioned in this article: Columbus Gold. Columbus Gold is not an advertiser on 321 Gold. I determined which companies would be included in this article based on my research and understanding of the sector.
2) The following companies mentioned are billboard sponsors of Streetwise Reports: Columbus Gold. Streetwise Reports does not accept stock in exchange for its services. Click here for important disclosures about sponsor fees. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
3) Statements and opinions expressed are the opinions of the author and not of Streetwise Reports or its officers. The author is wholly responsible for the validity of the statements. The author was not paid by Streetwise Reports for this article. Streetwise Reports was not paid by the author to publish or syndicate this article.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article, until one week after the publication of the interview or article.

( Companies Mentioned: CGT:TSX; CBGDF:OTCQX, )



from Streetwise Reports - Exclusive Articles https://www.streetwisereports.com/pub/na/17776

Miner Exceeds Estimates for Gold Produced in Q3/17

Source: Streetwise Reports   10/19/2017

BMO Capital Markets reported the preliminary Q3/17 production results for this senior gold producer.

According to an Oct. 16 research note, Yamana Gold Inc. (YRI:TSX; AUY:NYSE; YAU:LSE) produced 257 Koz gold in Q3/17 from six of its seven mines (excluding Brio). The quantity achieved surpassed BMO Capital Markets' expected 240 Koz "based on better-than-expected production from Chapada, Malartic and El Peñón, offset by lower production at Minera Florida," indicated analyst Andrew Kaip.

As for other metals, Yamana produced 37.1 Mlb copper, which beat BMO's anticipated 33.9 Mlb, Kaip added. It generated 1.43 Moz silver, which was in line with BMO's estimate.

About the Canadian miner's Q3 performance, Kaip concluded that "incorporating the stronger-than-expected production results is expected to have a positive impact to earnings."

Yamana's gold production for the first three quarters of 2017 is 717 Koz, Kaip noted. This represents about 76% of its 940 Koz gold production guidance for this year. Although the company increased its guidance for gold once already in 2017, it is "currently evaluating whether or not to increase production guidance for gold, silver and copper based on year-to-date production and an expected strong Q4/17," he wrote.

Kaip also noted that as of Sept. 30, Yamana had "approximately $125 million in cash."

This metals producer will report complete Q3/17 operational and financial results on Oct. 26 followed by a conference call on Oct. 27.

BMO Capital has a Market Perform rating and $3.25 per share price target for Yamana, whose shares are trading at around $2.64 per share.

Want to read more Gold Report articles like this? Sign up for our free e-newsletter, and you'll learn when new articles have been published. To see a list of recent articles and interviews with industry analysts and commentators, visit our Streetwise Interviews page.

Disclosure:
1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are sponsors of Streetwise Reports: None. Streetwise Reports does not accept stock in exchange for its services. Click here for important disclosures about sponsor fees. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article, until one week after the publication of the interview or article.

Additional disclosures about the sources cited in this article

( Companies Mentioned: YRI:TSX; AUY:NYSE; YAU:LSE, )



from Streetwise Reports - Exclusive Articles https://www.streetwisereports.com/pub/na/17779

Wednesday, October 18, 2017

Biotech Releases Initial Zika Vaccine Trial Results; Advances Combo Trials

Source: Streetwise Reports   10/18/2017

With multiple candidates in the pipeline advancing through clinical trials, Ram Selvaraju, an analyst with H.C. Wainwright & Co., provided insight into developments at a biotech addressing Zika virus, advanced bladder cancer and cervical dysplasia.

In an Oct. 6 research note, Selvaraju reported that the New England Journal of Medicine published the results from Inovio Pharmaceuticals Inc.'s (INO:NASDAQ) "first Phase 1 trial in humans of DNA-based Zika vaccine (GLS-5700)."

Selvaraju concluded the trial outcomes "demonstrate GLS-5700's potential efficacy in preventing Zika virus infection in humans together with a solid safety profile and bode well for the potential data readout from the second human trial around mid-2018."

In this Phase 1 study, 20 subjects received 1 mg and 20 subjects received 2 mg of GLS-5700 intradermally, Selvaraju wrote. The vaccine "induced high levels of binding antibodies in all participants after a three-dose vaccination regimen at 14 weeks," he noted, adding "neutralizing antibodies developed in 62% of the samples on Vero-cell assay."

Further, the analyst wrote, "On neuronal-cell assay, there was 90% inhibition of Zika virus infection in 70% of the serum samples and 50% inhibition in 95% of the samples. No serious adverse events were observed."

Inovio's second trial involving its Zika vaccine, another Phase 1 study (ZIKA-002), is already underway. Enrollment of 160 adults in Puerto Rico is complete. "This is a randomized, placebo-controlled, double-blind trial with 80 subjects receiving vaccine and 80 receiving placebo, designed to explore a potential trend toward clinical efficacy," Selvaraju explained.

In an Oct. 17 research report, Selvaraju commented on the initiation of a "Phase 1b/2 immuno-oncology trial in advanced bladder cancer" with a combination of INO-5401, INO-9012 and Tecentriq, produced by Genentech/Roche Holding AG (RHHBY:OTCQX).

"Approximately 80 patients with advanced unresectable or metastatic urothelial carcinoma (UC) are slated to be enrolled, the majority of whom would have previously received and failed to respond to an anti-PD-1 or PD-L1 checkpoint inhibitor alone," Selvaraju wrote. "The combination of checkpoint inhibition and [Inovio's] T cell activation could improve the response rate in this patient group, who have limited treatment options."

The analyst also noted that, "If T cell activators can indeed deliver a synergistic therapeutic effect with checkpoint inhibitors, this could immensely improve clinical outcomes by prolonging survival in patients with metastatic disease, in our view."

Near term for Inovio, another of its drug candidates, VGX-3100 for treatment of cervical dysplasia, is in enrollment for the Phase 3 REVEAL 1 trial, which is expected to begin in Q4/17. "Each study is slated to enroll 198 patients in over 100 centers globally," wrote Selvaraju.

H.C. Wainwright reiterates its Buy rating and $13 per share price target on Inovio, whose stock is currently trading at around $6.25 per share.

Want to read more Life Sciences Report articles like this? Sign up at www.streetwisereports.com/get-news for our free e-newsletter, and you'll learn when new articles have been published. To see recent articles and interviews with industry analysts and commentators, visit our Streetwise Interviews page.

Disclosure:
1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
2) Tracy Salcedo contributed to this article for Streetwise Reports LLC and provides services to Streetwise reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
3) The following company mentioned in this article is a sponsor of Streetwise Reports: Inovio Pharmaceuticals Inc. Streetwise Reports does not accept stock in exchange for its services. Click here for important disclosures about sponsor fees. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers.
5) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
6) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article, until one week after the publication of the interview or article.

Additional disclosures about the sources cited in this article

( Companies Mentioned: INO:NASDAQ, )



from Streetwise Reports - Exclusive Articles https://www.streetwisereports.com/pub/na/17775